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Article

Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7-deficient female mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2012

Aguila Hector L, Mun Se Hwan, Kalinowski Judith, Adams Douglas J, Lorenzo Joseph A, Lee Sun-Kyeong

Abstract excerpt

Interleukin-7 is a critical cytokine for lymphoid development and a direct inhibitor of in vitro osteoclastogenesis in murine bone marrow cultures. To explore the role of IL-7 in bone, we generated transgenic mouse lines bearing the 2.3-kb rat collagen 1α1 promoter driving the expression of human IL-7 specifically in osteoblasts. In addition, we crossed these mice with IL-7-deficient mice to determine if the...

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Identifiers

PMID: 22258693
DOI: 10.1002/jbmr.1553
PMCID: PMC3361560

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