Article

Novel antibiotic mode of action by repression of promoter isomerisation

2021-01-02

Abstract excerpt

Rising levels of antibiotic resistance dictate that new antibiotics with novel modes of action must be found. Here, we investigated the mode of action of a novel antibiotic that is a member of a family of synthetic DNA minor groove binding (MGB) molecules. MGB-BP-3 has successfully completed a Phase II clinical trial in humans as an orally administered drug for the treatment of chronic Clostridioides ( Clostridi...

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Literature Corpus work: a4c4fb39-cd3f-5f01-91d5-060718ed1f27
DOI: 10.1101/2020.12.31.424950

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