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Article

Deciphering the Impact of Temperature on Pleiotropic Consequences of RNA Polymerase Mutations.

Molecular biology and evolution - 1 Oct 2025

Ozbilek Deniz, Soley Jake K, Gifford Danna R, Knight Christopher G, Lovell Simon C, Lagator Mato

Abstract excerpt

Despite occurring in an essential molecule, mutations in RNA polymerase readily emerge and elicit complex pleiotropic effects across different levels of biological organization, which are all modulated by environment. We investigated the impact of temperature on the effects of six mutations on sequence, structure, transcriptome, and organismal traits. We found temperature altered the transcriptomic response and...

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Identifiers

PMID: 40972546
DOI: 10.1093/molbev/msaf226
PMCID: PMC12503110

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