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Article

Polycystin-1 Activates and Stabilizes the Polycystin-2 Channel

1 Jan 2003

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent genetic disorder largely caused by mutations in the PKD1 and PKD2 genes that encode the transmembrane proteins polycystin-1 and -2, respectively. Both proteins appear to be involved in the regulation of cell growth and maturation, but the precise mechanisms are not yet well defined. Polycystin-2 has recently been shown to function as a...

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PMID: 12407099
DOI: 10.1074/jbc.m209996200

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Polycystin-1 Activates and Stabilizes the Polycystin-2 ChannelPMID 12407099Read ↗

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Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Semantic proximity Read ↗

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Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Semantic proximity Read ↗

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