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Article

Polycystin-2 is an intracellular calcium release channel.

Nature cell biology - 1 Mar 2002

Koulen Peter, Cai Yiqiang, Geng Lin, Maeda Yoshiko, Nishimura Sayoko, Witzgall Ralph, Ehrlich Barbara E, Somlo Stefan

Abstract excerpt

Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP) channel superfamily, which is expressed abundantly in the endoplasmic reticulum (ER) membrane. Here, we show by single channel studies that polycystin-2 behaves as a calcium-activated, high conductance ER channel that is...

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Identifiers

PMID: 11854751
DOI: 10.1038/ncb754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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