Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nod2 mutation enhances NF-kappa B activity and bacterial killing activity of macrophages.

Inflammation - 1 Dec 2009

Tsay Tzyy-Bin, Chang Chien-Jen, Chen Pei-Hsuan, Hsu Ching-Mei, Chen Lee-Wei

Abstract excerpt

NOD2, an intracellular sensor of bacteria, are linked to increased susceptibility to bacteria in Crohn's disease (CD). The NOD2 protein is expressed mainly by macrophages and dendritic cells. This study is to examine the role of NOD2 in the innate response of macrophages to bacterial challenge. F...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crohn Disease
Share to Immunity, Innate
Share to Macrophages, Alveolar

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages, Peritoneal

Share to Mice, Knockout

Share to NF-kappa B

Share to Nod2 Signaling Adaptor Protein

Share to Pseudomonas aeruginosa

Source

Identifiers

PMID: 19728064
DOI: 10.1007/s10753-009-9145-z

Genes

NOD2
TLR4
TLR2
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19728064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nod2 mutation enhances NF-kappa B activity and bacterial killing activity of macrophages.PMID 19728064Read ↗

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.Semantic proximity Read ↗

Innate Immune Sensing of Microbes by Nod ProteinsSemantic proximity Read ↗

Resolving the field: a role for Nod2 in T cells.Semantic proximity Read ↗

Nod1 and Nod2 in innate immunity and human inflammatory disorders.Semantic proximity Read ↗

Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.Semantic proximity Read ↗

Insights into the molecular basis of the NOD2 signalling pathwaySemantic proximity Read ↗

NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease.Semantic proximity Read ↗

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionSemantic proximity Read ↗

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease.Semantic proximity Read ↗

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease.Semantic proximity Read ↗

The protein Nod2: an innate receptor more complex than previously assumed.Semantic proximity Read ↗

How NOD2 mutations predispose to Crohn's disease?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.