Article

The Mitochondrial F-box protein 1 and DJ-1 homolog HSP31 support cellular proteostasis during mitochondrial protein import clogging

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial biogenesis requires the import of ∼1,000-1,500 nuclear-encoded proteins across the Translocase of Outer Membrane (TOM) and the Translocase of Inner Membrane (TIM) 22 or 23 complexes. Protein import defects cannot only impair mitochondrial respiration but also cause mitochondrial Precursor Overaccumulation Stress (mPOS) in the cytosol. Recent studies showed that specific mutations i...

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Literature Corpus work: 442b134a-7830-5360-94f7-77476303cdc6
DOI: 10.1101/2025.10.13.682092

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