Article
Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.
The Journal of clinical investigation - 1 May 1992
Nesbitt T, Coffman T M, Griffiths R, Drezner M K
Abstract excerpt
Although deranged phosphate transport is the fundamental abnormality in X-linked hypophosphatemic (XLH) rickets, it remains unknown if this defect is the consequence of an intrinsic kidney abnormality or aberrant production of a humoral factor. To discriminate between these possibilities, we examined phosphate homeostasis in normal and Hyp mice, subjected to renal crosstransplantation. We initially evaluated the...
Topics
- Animals
- Glomerular Filtration Rate
- Homeostasis
- Hypophosphatemia, Familial
- Kidney
- Kidney Transplantation
- Mice
- Mice, Mutant Strains
- Phenotype
- Phosphates
- X Chromosome