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Article

Conserved loci on the X chromosome confer phosphate homeostasis in mice and humans.

Genetical research - 1 Jan 2000

Scriver C R, Tenenhouse H S

Abstract excerpt

Several genes expressed in kidney and other tissues determine phosphate homeostasis in extracellular fluid. The major form of inherited hypophosphatemia in humans involves an X-linked locus (HPDR, Xp22.31-p21.3). It has two murine homologues (Hyp and Gy) which map to closely-linked but separate loci (crossover value 0.4%-0.8%). Both murine mutations impair Na(+)-phosphate cotransport in renal brush border...

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Identifiers

PMID: 2177024
DOI: 10.1017/s0016672300035229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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