Article
Conserved loci on the X chromosome confer phosphate homeostasis in mice and humans.
Genetical research - 1 Jan 2000
Scriver C R, Tenenhouse H S
Abstract excerpt
Several genes expressed in kidney and other tissues determine phosphate homeostasis in extracellular fluid. The major form of inherited hypophosphatemia in humans involves an X-linked locus (HPDR, Xp22.31-p21.3). It has two murine homologues (Hyp and Gy) which map to closely-linked but separate l...
Topics
- Animals
- Female
- Genes
- Genetic Linkage
- Homeostasis
- Humans
- Hypophosphatemia, Familial
- Intestinal Mucosa
- Kidney Tubules, Proximal
- Male
- Mice
- Phenotype
- Phosphates
- X Chromosome