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Article

Phosphate transport in renal cell cultures of gy mice: evidence of a single defect in X-linked hypophosphatemia.

The American journal of physiology - 1 Jul 1997

Nesbitt T, Drezner M K

Abstract excerpt

Although current theory holds that the murine homologs of X-linked hypophosphatemia represent mutations of two closely linked genes with distinct pathophysiological consequences, insufficient data are available to support this hypothesis. We investigated whether an intrinsic defect in renal sodium (Na+)-dependent Pi cotransport truly distinguishes gy from hyp mice. We compared Pi transport in immortalized cells...

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Identifiers

PMID: 9249598
DOI: 10.1152/ajprenal.1997.273.1.F113

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Phosphate transport in renal cell cultures of gy mice: evidence of a single defect in X-linked hypophosphatemia.PMID 9249598Read ↗

Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: evidence that the HYP gene locus product is an extrarenal factor.Semantic proximity Read ↗

Renal expression of Na+-phosphate cotransporter mRNA and protein: effect of the Gy mutation and low phosphate diet.Semantic proximity Read ↗

X-linked hypophosphatemic Gy mice: renal tubular maximum for phosphate vs. brush-border transport after low-P diet.Semantic proximity Read ↗

Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse.Semantic proximity Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

Intestinal malabsorption of 45calcium in young Gy mice, a second model for X-linked hypophosphatemia.Semantic proximity Read ↗

Conserved loci on the X chromosome confer phosphate homeostasis in mice and humans.Semantic proximity Read ↗

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Functional properties of proximal tubule cell lines derived from transgenic mice harboring L-pyruvate kinase-SV40 (T) antigen hybrid gene.Semantic proximity Read ↗

Renal phosphate wasting in the absence of adenylyl cyclase 6.Semantic proximity Read ↗

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