Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: evidence that the HYP gene locus product is an extrarenal factor.

Abstract excerpt

Whether renal phosphate wasting in X-linked hypophosphatemia (XLH) results from an intrinsic renal or humoral defect remains controversial. In studies of the murine homolog of XLH, harboring the Simian Virus 40 (SV40) large T antigen, we obviated the influence of renal cell heterogeneity and impressed memory by comparing Na(+)-phosphate cotransport in immortalized cells from the S1 segment of the proximal tubule....

Topics

• Animals
• Biological Transport
• Cell Line, Transformed
• Cell Survival
• Chromosome Mapping
• Hypophosphatemia, Familial
• Kidney Tubules, Proximal
• Kinetics
• Mice
• Mice, Transgenic