Article
Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse.
Kidney international - 1 Nov 1996
Lajeunesse D, Meyer R A, Hamel L
Abstract excerpt
The murine Hyp model reproduces the characteristics of human X-linked hypophosphatemia (XLH), an inherited disease causing renal loss of phosphate (Pi), severe rickets and osteomalacia. A current hypothesis considers that a humoral factor may be responsible for the renal Pi loss, although in vitr...
Topics
- Adaptation, Physiological
- Amino Acids
- Animals
- Biological Transport, Active
- Cells, Cultured
- Culture Media, Conditioned
- Glucose
- Humans
- Hypophosphatemia, Familial
- Kidney
- Kidney Tubules, Proximal
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Osteoblasts
- Phenotype
- Phosphates