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Article

Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse.

Kidney international - 1 Nov 1996

Lajeunesse D, Meyer R A, Hamel L

Abstract excerpt

The murine Hyp model reproduces the characteristics of human X-linked hypophosphatemia (XLH), an inherited disease causing renal loss of phosphate (Pi), severe rickets and osteomalacia. A current hypothesis considers that a humoral factor may be responsible for the renal Pi loss, although in vitro experiments with renal cell models have failed to demonstrate the presence of such a factor in XLH or in the Hyp...

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Source

Identifiers

PMID: 8914019
DOI: 10.1038/ki.1996.468

Genes

AVP
PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse.PMID 8914019Read ↗

Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: evidence that the HYP gene locus product is an extrarenal factor.Semantic proximity Read ↗

Effect of phosphate supplementation on the expression of the mutant phenotype in murine X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.Semantic proximity Read ↗

Phosphate transport in renal cell cultures of gy mice: evidence of a single defect in X-linked hypophosphatemia.Semantic proximity Read ↗

Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.Semantic proximity Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

Renal expression of Na+-phosphate cotransporter mRNA and protein: effect of the Gy mutation and low phosphate diet.Semantic proximity Read ↗

Early lethality in Hyp mice with targeted deletion of Pth gene.Semantic proximity Read ↗

Conserved loci on the X chromosome confer phosphate homeostasis in mice and humans.Semantic proximity Read ↗

Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.Semantic proximity Read ↗

Intestinal malabsorption of 45calcium in young Gy mice, a second model for X-linked hypophosphatemia.Semantic proximity Read ↗

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