Article
Effect of phosphate supplementation on the expression of the mutant phenotype in murine X-linked hypophosphatemic rickets.
Bone - 1 Jan 2000
Tenenhouse H S, Martel J, Rubin J, Harvey N
Abstract excerpt
The X-linked Hyp mouse, a murine homologue of X-linked hypophosphatemia in humans, is characterized by rachitic bone disease, hypophosphatemia, impaired renal brush-border membrane Na(+)-phosphate cotransport and abnormal regulation of renal vitamin D metabolism. We demonstrated that short-term phosphate supplementation decreases renal 1,25-dihydroxyvitamin D3 (1,25-(OH)2D) catabolism and increases serum...
Topics
- Alkaline Phosphatase
- Analysis of Variance
- Animals
- Bilirubin
- Blood Proteins
- Calcitriol
- Cyclic AMP
- Dihydroxycholecalciferols
- Disease Models, Animal
- Electrophoresis, Polyacrylamide Gel
- Female