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Article

Effect of phosphate supplementation on the expression of the mutant phenotype in murine X-linked hypophosphatemic rickets.

Bone - 1 Jan 2000

Tenenhouse H S, Martel J, Rubin J, Harvey N

Abstract excerpt

The X-linked Hyp mouse, a murine homologue of X-linked hypophosphatemia in humans, is characterized by rachitic bone disease, hypophosphatemia, impaired renal brush-border membrane Na(+)-phosphate cotransport and abnormal regulation of renal vitamin D metabolism. We demonstrated that short-term phosphate supplementation decreases renal 1,25-dihydroxyvitamin D3 (1,25-(OH)2D) catabolism and increases serum...

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Source

Identifiers

PMID: 7873297
DOI: 10.1016/8756-3282(94)90317-4

Genes

PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of phosphate supplementation on the expression of the mutant phenotype in murine X-linked hypophosphatemic rickets.PMID 7873297Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous disorder in humans and mice.Semantic proximity Read ↗

X-linked hypophosphataemia: a homologous phenotype in humans and mice with unusual organ-specific gene dosage.Semantic proximity Read ↗

Conserved loci on the X chromosome confer phosphate homeostasis in mice and humans.Semantic proximity Read ↗

Femoral abnormalities and vitamin D metabolism in X-linked hypophosphatemic (Hyp and Gy) mice.Semantic proximity Read ↗

Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets.Semantic proximity Read ↗

Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.Semantic proximity Read ↗

Intestinal malabsorption of 45calcium in young Gy mice, a second model for X-linked hypophosphatemia.Semantic proximity Read ↗

Renal expression of Na+-phosphate cotransporter mRNA and protein: effect of the Gy mutation and low phosphate diet.Semantic proximity Read ↗

Craniofacial abnormalities in mice with X-linked hypophosphatemic genes (Hyp or Gy).Semantic proximity Read ↗

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