Article
Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport.
American journal of physiology. Cell physiology - 1 Nov 2002
Dubois Stéphanie G, Ruchon Andréa Frota, Delalandre Aline, Boileau Guy, Lajeunesse Daniel
Abstract excerpt
We investigated whether the absence of Phex (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) in the Hyp mouse affects the expression and activity of neprilysin (NEP) and of endothelin-converting enzyme-like endopeptidase (ECEL1/DINE) in bone marrow stromal cells (BMSC) and osteoblasts (Ob). Total NEP-like activity was higher in Ob than in BMSC regardless of genotype, and Hyp cells...
Topics
- Animals
- Bone and Bones
- Cell Line
- Gene Expression
- Hypophosphatemia
- Kidney Tubules, Proximal
- Male
- Metalloendopeptidases
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains