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Article

Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog.

Developmental cell - 1 Feb 2005

Glise Bruno, Miller Catherine A, Crozatier Michèle, Halbisen Michael A, Wise Steve, Olson David J, Vincent Alain, Blair Seth S

Abstract excerpt

We here identify and characterize an extracellular modulator of Hedgehog signaling in Drosophila, Shifted. Shifted is required for high levels of long-range signaling in the developing wing imaginal disc. Surprisingly, shifted encodes the only Drosophila ortholog of the secreted vertebrate protein Wnt Inhibitory Factor-1 (WIF-1), whose known role is to bind to extracellular Wnts and inhibit their activity....

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Share to Adaptor Proteins, Signal Transducing
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hedgehog Proteins

Share to Heparan Sulfate Proteoglycans

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Source

Identifiers

PMID: 15691766
DOI: 10.1016/j.devcel.2005.01.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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