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Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.

Developmental biology - 15 Apr 2013

Bilioni Aphrodite, Sánchez-Hernández David, Callejo Ainhoa, Gradilla Ana-Citlali, Ibáñez Carmen, Mollica Emanuela, Carmen Rodríguez-Navas M, Simon Eléanor, Guerrero Isabel

Abstract excerpt

Hedgehog can signal both at a short and long-range, and acts as a morphogen during development in various systems. We studied the mechanisms of Hh release and spread using the Drosophila wing imaginal disc as a model system for polarized epithelium. We analyzed the cooperative role of the glypican Dally, the extracellular factor Shifted (Shf, also known as DmWif), and the Immunoglobulin-like (Ig-like) and...

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PMID: 23276604
DOI: 10.1016/j.ydbio.2012.12.013

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