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Article

HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.

Developmental cell - 1 May 2002

Giráldez Antonio J, Copley Richard R, Cohen Stephen M

Abstract excerpt

The secreted signaling protein Wingless acts as a morphogen to pattern the imaginal discs of Drosophila. Here we report identification of a secreted repressor of Wingless activity, which we call Notum. Loss of Notum function leads to increased Wingless activity by altering the shape of the Wingle...

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Identifiers

PMID: 12015973
DOI: 10.1016/s1534-5807(02)00180-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12015973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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