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Article

Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase.

Science (New York, N.Y.) - 31 Aug 2001

Dhoot G K, Gustafsson M K, Ai X, Sun W, Standiford D M, Emerson C P

Abstract excerpt

The developmental signaling functions of cell surface heparan sulfate proteoglycans (HSPGs) are dependent on their sulfation states. Here, we report the identification of QSulf1, the avian ortholog of an evolutionarily conserved protein family related to heparan-specific N-acetyl glucosamine sulfatases. QSulf1 expression is induced by Sonic hedgehog in myogenic somite progenitors in quail embryos and is required...

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Identifiers

PMID: 11533491
DOI: 10.1126/science.293.5535.1663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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