Article
A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.
Genetics - 1 Mar 2008
Casso David J, Liu Songmei, Iwaki D David, Ogden Stacey K, Kornberg Thomas B
Abstract excerpt
Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases. Although components of the signaling pathway have been identified, key aspects of the signaling mechanism and downstream targets remain to be elucidated. We performed an enhancer/suppressor screen in Drosophila to identify novel components of...
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