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Article

c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation.

Developmental cell - 1 Feb 2005

Sandberg Mark L, Sutton Susan E, Pletcher Mathew T, Wiltshire Tim, Tarantino Lisa M, Hogenesch John B, Cooke Michael P

Abstract excerpt

Precise control of hematopoietic stem cell (HSC) proliferation and differentiation is needed to maintain a lifetime supply of blood cells. Using genome-wide ENU mutagenesis and phenotypic screening, we have identified a mouse line that harbors a point mutation in the transactivation (TA) domain of the transcription factor c-Myb (M303V), which reduces c-Myb-dependent TA by disrupting its interaction with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15691758
DOI: 10.1016/j.devcel.2004.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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