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Article

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.

Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002

Rebel Vivienne I, Kung Andrew L, Tanner Elizabeth A, Yang Hong, Bronson Roderick T, Livingston David M

Abstract excerpt

Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional coactivators CREB-binding protein (CBP) and p300 in such HSC fate decisions. A full dose of CBP, but not p300...

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Source

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Identifiers

PMID: 12397173
DOI: 10.1073/pnas.232568499
PMCID: PMC137497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12397173-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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