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Article

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice.

Blood - 15 Oct 2008

Kauppi Maria, Murphy James M, de Graaf Carolyn A, Hyland Craig D, Greig Kylie T, Metcalf Donald, Hilton Adrienne A, Nicola Nicos A, Kile Benjamin T, Hilton Douglas J, Alexander Warren S

Abstract excerpt

In an N-nitroso-N-ethylurea (ENU) mutagenesis screen using Mpl(-/-) mice, we isolated a semidominant suppressor of thrombocytopenia, termed Plt6. The gene mutated in Plt6 mice encodes the transcriptional coregulator p300, and the mutation, a tyrosine to asparagine substitution at amino acid 630 (Y630N), disrupts the interaction between p300 and c-Myb. Mpl(-/-) p300(Plt6/+) mice displayed elevated platelet counts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-myb

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Source

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Identifiers

PMID: 18684867
DOI: 10.1182/blood-2007-10-119677
PMCID: PMC2569170

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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