Article
Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved.
Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2010
Soza-Ried Cristian, Hess Isabell, Netuschil Nikolai, Schorpp Michael, Boehm Thomas
Abstract excerpt
The transcription factor c-myb has emerged as one of the key regulators of vertebrate hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but essentially required for definitive hematopoiesis. Using a conditional knock-out strategy, recent studies have indicated that c-myb is required for self-renewal of mouse hematopoietic stem cells. Here, we describe and characterize the...
Topics
- Animals
- Animals, Genetically Modified
- Biological Evolution
- Hematopoiesis
- Hematopoietic Stem Cells
- In Situ Hybridization
- Mice
- Molecular Sequence Data
- Mutation
- Phenotype
- Protein Conformation
- Proto-Oncogene Proteins c-myb
- Thymus Gland
- Zebrafish