Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia.

Abstract excerpt

The transcription factor c-Myb and coregulator p300 have a key role in maintaining production of controlled numbers of megakaryocytes and platelets. In mice, mutations in c-Myb or p300 cause thrombocytosis in otherwise wild-type animals and can ameliorate the thrombocytopenia in mice lacking the thrombopoietin receptor, c-Mpl, a model for human congenital amegakaryocytic thrombocytopenia. To examine whether...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to bcl-X Protein
• Share to Cytoprotection
• Share to E1A-Associated p300 Protein