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Article

Impairment of microtubule‐dependent trafficking by overexpression of α‐synuclein

1 Dec 2006

Abstract excerpt

Abnormal accumulation of alpha-synuclein (alpha-syn) has been linked to several neurological disorders, including Parkinson's disease (PD). However, the underlying mechanism by which alpha-syn accumulation affects neuronal function and survival remains unknown. Here, we provide data suggesting a possible effect of aggregated alpha-syn on the microtubule (MT) network. Consistent with the MT dysfunction, we also...

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PMID: 17156376
DOI: 10.1111/j.1460-9568.2006.05210.x

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