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Article

α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

7 Sept 2006

Abstract excerpt

Alpha-synuclein is a neuronal protein implicated genetically in Parkinson's disease. alpha-synuclein localizes to the nucleus and presynaptic nerve terminals. Here we show that alpha-synuclein mediates neurotoxicity in the nucleus. Targeting of alpha-synuclein to the nucleus promotes toxicity, whereas cytoplasmic sequestration is protective in both cell culture and transgenic Drosophila. Toxicity of...

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PMID: 16959795
DOI: 10.1093/hmg/ddl243

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