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Article

Nuclear Localization of α-Synuclein and Its Interaction with Histones

24 Jun 2003

Abstract excerpt

The aggregation of alpha-synuclein is believed to play an important role in the pathogenesis of Parkinson's disease as well as other neurodegenerative disorders ("synucleinopathies"). However, the function of alpha-synuclein under physiologic and pathological conditions is unknown, and the mechanism of alpha-synuclein aggregation is not well understood. Here we show that alpha-synuclein forms a tight 2:1 complex...

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PMID: 12859192
DOI: 10.1021/bi0341152

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