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Article

PKA/AKAP1 and PP2A/Bβ2 regulate neuronal morphogenesis via Drp1 phosphorylation and mitochondrial bioenergetics.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Nov 2011

Dickey Audrey S, Strack Stefan

Abstract excerpt

Mitochondrial shape is determined by fission and fusion reactions, perturbation of which can contribute to neuronal injury and disease. Mitochondrial fission is catalyzed by dynamin-related protein 1 (Drp1), a large GTPase of the dynamin family that is highly expressed in neurons and regulated by various posttranslational modifications, including phosphorylation. We report here that reversible phosphorylation of...

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Source

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Identifiers

PMID: 22049414
DOI: 10.1523/JNEUROSCI.3159-11.2011
PMCID: PMC3328351

Genes

AKAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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