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Article

Correlation between a single nucleotide polymorphism in the matrix metalloproteinase-2 promoter and risk of lung cancer.

Cancer research - 15 Nov 2002

Yu Chunyuan, Pan Kaifeng, Xing Deyin, Liang Gang, Tan Wen, Zhang Lian, Lin Dongxin

Abstract excerpt

Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single nucleotide polymorphism (-1306C-->T) in the MMP2 promoter sequence disrupts an Sp1 site and thus results in strikingly lower promoter activity. We examined the relationship between this polymorphism and risk for lung cancer in 781 cases and 852 age- and sex-matched controls in a Chinese population. We found...

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Case-Control Studies
China
Lung Neoplasms
Matrix Metalloproteinase 2
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12438229

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MMP2

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