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Article

Functional Significance of MMP3 and TIMP2 Polymorphisms in Cleft Lip/Palate.

Journal of dental research - 1 Jul 2014

Letra A, Zhao M, Silva R M, Vieira A R, Hecht J T

Abstract excerpt

Evidence from biological and human studies strongly supports a role for MMP and TIMP genes as candidate genes for non-syndromic cleft lip with or without cleft palate (NSCL/P). We previously showed the association of promoter polymorphisms in MMP3 (rs3025058 and rs522616) and TIMP2 (rs8179096) with NSCL/P. In this study, we examined the functional significance of these polymorphisms. A specific DNA-protein...

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Topics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24799419
DOI: 10.1177/0022034514534444
PMCID: PMC4107548

Genes

MMP3
TIMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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