Article
A functional polymorphism (-1607 1G→2G) in the matrix metalloproteinase-1 promoter is associated with development and progression of lung cancer.
Cancer - 15 Nov 2011
Liu Li, Wu Jing, Wu Chen, Wang Ying, Zhong Rong, Zhang Xinyu, Tan Wen, Nie Shaofa, Miao Xiaoping, Lin Dongxin
Abstract excerpt
BACKGROUND: Matrix metalloproteinase-1 (MMP-1), an interstitial collagenase, plays an important role in the breakdown of extracellular matrix and mediates pathways of apoptosis, angiogenesis, and immunity. It has been demonstrated that the overexpression of this enzyme is associated with tumor initiation, invasion, and metastasis. The -1607 single guanine (1G)-to-2G polymorphism (reference single nucleotide...
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