Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.

doi:10.1016/j.neulet.2004.01.016

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Article

Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.

Neuroscience letters - 25 Mar 2004

Cook Lynnette J, Ho Luk W, Taylor Alison E, Brayne Carol, Evans John Grimley, Xuereb John, Cairns Nigel J, Pritchard Antonia, Lemmon Helen, Mann David, St Clair David, Turic Dragana, Hollingworth Paul, Moore Pamela J, Jehu Luke, Archer Nicola, Walter Sarah, Foy Catherine, Edmondson Amanda, Powell John, Lovestone Simon, Owen Michael J, Williams Julie, Lendon Corinne, Rubinsztein David C

Abstract excerpt

Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acetylcholine receptors in the brains of AD patients. Knockout mice for the beta2 subunit have impaired neuronal survival in ageing. Accordingly, we have analysed polymorphisms in the genes that encode the alpha4 and beta2 subunits, CHRNA4 and CHRNB2 respectively, for...

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Identifiers

PMID: 15026168
DOI: 10.1016/j.neulet.2004.01.016

Genes

CHRNB2
CHRNA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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