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Article

Genome-wide single-nucleotide polymorphism arrays demonstrate high fidelity of multiple displacement-based whole-genome amplification.

Electrophoresis - 1 Feb 2005

Tzvetkov Mladen V, Becker Christian, Kulle Bettina, Nürnberg Peter, Brockmöller Jürgen, Wojnowski Leszek

Abstract excerpt

Whole-genome DNA amplification by multiple displacement (MD-WGA) is a promising tool to obtain sufficient DNA amounts from samples of limited quantity. Using Affymetrix' GeneChip Human Mapping 10K Arrays, we investigated the accuracy and allele amplification bias in DNA samples subjected to MD-WGA. We observed an excellent concordance (99.95%) between single-nucleotide polymorphisms (SNPs) called both in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15690424
DOI: 10.1002/elps.200410121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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