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Article

Unbiased whole-genome amplification directly from clinical samples.

Genome research - 1 May 2003

Hosono Seiyu, Faruqi A Fawad, Dean Frank B, Du Yuefen, Sun Zhenyu, Wu Xiaohong, Du Jing, Kingsmore Stephen F, Egholm Michael, Lasken Roger S

Abstract excerpt

Preparation of genomic DNA from clinical samples is a bottleneck in genotyping and DNA sequencing analysis and is frequently limited by the amount of specimen available. We use Multiple Displacement Amplification (MDA) to amplify the whole genome 10,000-fold directly from small amounts of whole blood, dried blood, buccal cells, cultured cells, and buffy coats specimens, generating large amounts of DNA for genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12695328
DOI: 10.1101/gr.816903
PMCID: PMC430878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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