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Article

Evaluation of genome coverage and fidelity of multiple displacement amplification from single cells by SNP array.

Molecular human reproduction - 1 Nov 2009

Ling Jiawei, Zhuang Guanglun, Tazon-Vega Barbara, Zhang Chenhui, Cao Baoqiang, Rosenwaks Zev, Xu Kangpu

Abstract excerpt

The scarce amount of DNA contained in a single cell is a limiting factor for clinical application of preimplantation genetic diagnosis mainly due to the risk of misdiagnosis caused by allele dropout and the difficulty in obtaining copy number variations in all 23 pairs of chromosomes. Multiple displacement amplification (MDA) has been reported to generate large quantity of products from small amount of templates....

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Identifiers

PMID: 19671595
DOI: 10.1093/molehr/gap066
PMCID: PMC2762374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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