Article
Two methods of whole-genome amplification enable accurate genotyping across a 2320-SNP linkage panel.
Genome research - 1 May 2004
Barker David L, Hansen Mark S T, Faruqi A Fawad, Giannola Diane, Irsula Orlando R, Lasken Roger S, Latterich Martin, Makarov Vladimir, Oliphant Arnold, Pinter Jonathon H, Shen Richard, Sleptsova Irina, Ziehler William, Lai Eric
Abstract excerpt
Comprehensive genome scans involving many thousands of SNP assays will require significant amounts of genomic DNA from each sample. We report two successful methods for amplifying whole-genomic DNA prior to SNP analysis, multiple displacement amplification, and OmniPlex technology. We determined the coverage of amplification by analyzing a SNP linkage marker set that contained 2320 SNP markers spread across the...
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