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Article

Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2016

Sung Yun-Min, Wilkins Angela D, Rodriguez Gustavo J, Wensel Theodore G, Lichtarge Olivier

Abstract excerpt

The structural basis of allosteric signaling in G protein-coupled receptors (GPCRs) is important in guiding design of therapeutics and understanding phenotypic consequences of genetic variation. The Evolutionary Trace (ET) algorithm previously proved effective in redesigning receptors to mimic the ligand specificities of functionally distinct homologs. We now expand ET to consider mutual information, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26979958
DOI: 10.1073/pnas.1516579113
PMCID: PMC4822589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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