The mosaic structure of variation in the laboratory mouse genome.

doi:10.1038/nature01252

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Article

The mosaic structure of variation in the laboratory mouse genome.

Nature - 5 Dec 2002

Wade Claire M, Kulbokas Edward J, Kirby Andrew W, Zody Michael C, Mullikin James C, Lander Eric S, Lindblad-Toh Kerstin, Daly Mark J

Abstract excerpt

Most inbred laboratory mouse strains are known to have originated from a mixed but limited founder population in a few laboratories. However, the effect of this breeding history on patterns of genetic variation among these strains and the implications for their use are not well understood. Here we present an analysis of the fine structure of variation in the mouse genome, using single nucleotide polymorphisms...

Topics

Albinism
Animals
Base Sequence
Genetic Variation
Genome
Haplotypes
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Monophenol Monooxygenase
Mutation
Phenotype
Polymorphism, Single Nucleotide
Recombination, Genetic

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PMID: 12466852
DOI: 10.1038/nature01252

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