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Article

The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases.

International journal of immunogenetics - 1 Feb 2005

Cipriano C, Caruso C, Lio D, Giacconi R, Malavolta M, Muti E, Gasparini N, Franceschi C, Mocchegiani E

Abstract excerpt

Abnormal increments of pro-inflammatory cytokines (IL-6 and TNF-alpha) characterize the outbreak of infectious diseases, which are the major cause of death in the elderly. A counterbalance to the inflammation is exerted by IL-10 with an inhibitory role on TNF-alpha production. As is well known, some cytokine gene polymorphisms influence the cytokine production, playing a role as susceptibility or resistance...

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Source

Identifiers

PMID: 15686588
DOI: 10.1111/j.1744-313X.2005.00490.x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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