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Article

The -308 (G/A) single nucleotide polymorphism in the TNF-alpha gene and the risk of major depression in the elderly.

International journal of geriatric psychiatry - 1 Mar 2010

Cerri Anna Paola, Arosio Beatrice, Viazzoli Chiara, Confalonieri Roberto, Vergani Carlo, Annoni Giorgio

Abstract excerpt

OBJECTIVE: The immune system (IS) plays a key role in the mechanisms underlying major depression (MD) and pro-inflammatory cytokines seem to be particularly involved in the pathogenesis of the disease. There is growing evidence of a relationship between commonly studied single nucleotide polymorphisms (SNPs) in cytokine genes and an increased risk of MD.The aim of our study was to investigate the association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19618378
DOI: 10.1002/gps.2323

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TNF

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