Article
The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing.
Experimental gerontology - 1 Apr 2004
Giacconi Robertina, Cipriano Catia, Albanese Francesco, Boccoli Gianfranco, Saba Vittorio, Olivieri Fabiola, Franceschi Claudio, Mocchegiani Eugenio
Abstract excerpt
High levels of IL-6 are coupled with impaired immune efficiency, morbidity and mortality in ageing. Elderly men with GG (C-) genotype in -174 locus of IL-6 promoter are disadvantaged for longevity due to higher IL-6 than CG or CC (C+) carriers. As IL-6 increases in atherosclerosis, the study of the polymorphism of IL-6 may be a useful tool in identifying old subjects at risk for atherosclerosis. Thus, we divided...
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