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Article

MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture.

The Journal of experimental medicine - 7 Feb 2005

Katz Elad, Lareef Mohamed H, Rassa John C, Grande Shannon M, King Leslie B, Russo Jose, Ross Susan R, Monroe John G

Abstract excerpt

Expression of immunoreceptor tyrosine-based activation motif (ITAM)-containing signaling proteins is normally restricted to hematopoietic tissues. The basal activity of ITAM-containing proteins is mediated through negative regulation by coreceptors restricted to hematopoietic tissues. We have identified an ITAM signaling domain encoded within the env gene of murine mammary tumor virus (MMTV). Three-dimensional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15684322
DOI: 10.1084/jem.20041471
PMCID: PMC2213037

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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