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Article

E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurin.

PloS one - 1 Jan 2012

Klingseisen Laura, Ehrenschwender Martin, Heigl Ulrike, Wajant Harald, Hehlgans Thomas, Schütze Stefan, Schneider-Brachert Wulf

Abstract excerpt

Escape from the host immune system is essential for intracellular pathogens. The adenoviral protein E3-14.7K (14.7K) is known as a general inhibitor of tumor necrosis factor (TNF)-induced apoptosis. It efficiently blocks TNF-receptor 1 (TNFR1) internalization but the underlying molecular mechanism still remains elusive. Direct interaction of 14.7K and/or associated proteins with the TNFR1 complex has been...

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Source

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Identifiers

PMID: 22675546
DOI: 10.1371/journal.pone.0038348
PMCID: PMC3366936

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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