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Article

BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM

23 Aug 2022

Abstract excerpt

The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily. BTLA and HVEM have both been implicated in the regulation of human T cell responses, but their role is complex and incompletely understood. Here, we have used T cell...

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Identifiers

PMID: 36081508
DOI: 10.3389/fimmu.2022.956694

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