Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM.

Virology - 1 Mar 2009

Hsiao Francis C, Tai Albert K, Deglon Agnes, Sutkowski Natalie, Longnecker Richard, Huber Brigitte T

Abstract excerpt

EBV encodes latent membrane protein (LMP)-2A that functions as a homologue of the activated BCR. We have previously shown that LMP-2A transactivates a human endogenous retrovirus, HERV-K18, in infected B-lymphocytes. The Env protein of HERV-K18 encodes a superantigen that strongly stimulates a large number of T cells. To delineate the mechanism through which LMP-2A transactivates HERV-K18 env, we tested a panel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Endogenous Retroviruses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 4, Human

Share to Interleukin-2

Share to Superantigens

Share to Transcriptional Activation

Share to Viral Matrix Proteins

Share to Virus Activation

Source

Identifiers

PMID: 19070345
DOI: 10.1016/j.virol.2008.11.025

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM.PMID 19070345Read ↗

Epstein-Barr Virus Latent Membrane Protein LMP-2A Is Sufficient for Transactivation of the Human Endogenous Retrovirus HERV-K18 SuperantigenSemantic proximity Read ↗

Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.Semantic proximity Read ↗

Cutting Edge: Epstein-Barr Virus Transactivates the HERV-K18 Superantigen by Docking to the Human Complement Receptor 2 (CD21) on Primary B CellsSemantic proximity Read ↗

Induction of EBV latent membrane protein-2A (LMP2A)-specific T cells and construction of individualized TCR-engineered T cells for EBV-associated malignanciesSemantic proximity Read ↗

Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigenSemantic proximity Read ↗

Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T CellsSemantic proximity Read ↗

Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell ModelSemantic proximity Read ↗

Role of the Immunoreceptor Tyrosine-Based Activation Motif of Latent Membrane Protein 2A (LMP2A) in Epstein-Barr Virus LMP2A-Induced Cell TransformationSemantic proximity Read ↗

The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Semantic proximity Read ↗

Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402–restricted Epstein-Barr virus–specific CD8+ T cellsSemantic proximity Read ↗

Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice.Semantic proximity Read ↗

The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-κB Signaling Downstream of TRAF2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.