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Article

Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death.

Free radical biology & medicine - 1 Mar 2005

Bota Daniela A, Ngo Jenny K, Davies Kelvin J A

Abstract excerpt

Lon now emerges as a major regulator of multiple mitochondrial functions in human beings. Lon catalyzes the degradation of oxidatively modified matrix proteins, chaperones the assembly of inner membrane complexes, and participates in the regulation of mitochondrial gene expression and genome integrity. An early result of Lon downregulation in WI-38 VA-13 human lung fibroblasts is massive caspase 3 activation and...

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Identifiers

PMID: 15683722
DOI: 10.1016/j.freeradbiomed.2004.11.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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