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Article

Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species.

Cell death & disease - 20 Jun 2013

Cheng C-W, Kuo C-Y, Fan C-C, Fang W-C, Jiang S S, Lo Y-K, Wang T-Y, Kao M-C, Lee A Y-L

Abstract excerpt

Lon protease is a multifunction protein and operates in protein quality control and stress response pathways in mitochondria. Human Lon is upregulated under oxidative and hypoxic stresses that represent the stress phenotypes of cancer. However, little literature undertakes comprehensive and detailed investigations on the tumorigenic role of Lon. Overexpression of Lon promotes cell proliferation, apoptotic...

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Identifiers

PMID: 23788038
DOI: 10.1038/cddis.2013.204
PMCID: PMC3702277

Genes

NDUFS8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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