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The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals.

Gene - 13 Mar 2003

Lu Bin, Liu Tong, Crosby Juan A, Thomas-Wohlever Jennifer, Lee Irene, Suzuki Carolyn K

Abstract excerpt

The ATP-dependent Lon protease is a multi-functional enzyme that is conserved from archae to mammalian mitochondria, which not only degrades protein substrates but also binds DNA. As a starting point toward understanding Lon function in development, the mouse Lon cDNA was cloned and the encoded protein was characterized in cultured mammalian cells, in yeast and in vitro. Mouse Lon shows 87, 40 and 33% amino acid...

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Identifiers

PMID: 12657466
DOI: 10.1016/s0378-1119(03)00403-7

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