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Article

Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q.

Cancer research - 1 May 1992

Yamaguchi T, Toguchida J, Yamamuro T, Kotoura Y, Takada N, Kawaguchi N, Kaneko Y, Nakamura Y, Sasaki M S, Ishizaki K

Abstract excerpt

We have investigated the involvement of tumor suppressor genes in the genesis of osteosarcoma by analyzing allele losses at polymorphic loci in tumor tissues. Genotypes of DNA from primary osteosarcoma tissue and corresponding normal cells from 37 patients were analyzed at 58 polymorphic loci representing each autosomal chromosome arm except 5p and 20q. Allele losses were found at polymorphic loci on 36 of 37...

Topics

Adolescent
Adult
Alleles
Child
Child, Preschool
Chromosome Deletion
Female
Genetic Markers
Humans
Lung Neoplasms
Male
Middle Aged

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Osteosarcoma

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PMID: 1568211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1568211-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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