Article
Protein kinase inhibitors in the treatment of pulmonary fibrosis.
Current medicinal chemistry - 1 Jan 2008
Garneau-Tsodikova Sylvie, Thannickal Victor J
Abstract excerpt
Fibrosis of the lung and other organ systems is an increasing cause of morbidity and mortality worldwide. Effective anti-fibrotic agents for such disorders are currently lacking. Injury to epithelium-lined tissues in mammals is typically associated with a mesenchymal response, including the activation of myofibroblasts. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease that results from...
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